Pharmacological properties: allopurinol - anti-gout drug that inhibits the synthesis of uric acid and its salts in the body. The preparation has a specific ability to inhibit xanthine oxidase enzyme involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This reduces the contents of urate in the blood plasma and prevents deposition in tissues and kidney. Using the drug reduced urinary excretion of uric acid and increased allocation more easily soluble hypoxanthine and xanthine. Allopurinol is converted in the body to alloksantin which prevents the formation of uric acid, but for activity yields allopurinol. After ingestion of about 90% of the drug is absorbed in the digestive tract. The maximum concentration of allopurinol in the blood plasma is reached after an average of 1.5 hours half-life of allopurinol is 1-2 hours, alloksantina - about 15 hours, so the inhibition of xanthine oxidase activity can last for 24 hours after a single dose. About 20% of the dose is excreted in the feces, the rest of the drug and its metabolites - the urine. Indications: diseases associated with hyperuricemia, including primary and secondary gout, kidney stones (with the formation of urate) , primary and secondary hyperuricemia that occurs in pathological processes involving enhanced dissolution of nucleoproteins and elevated levels of uric acid in the blood, including various gemoblastomy (acute leukemia, lymphosarcoma, etc.), the condition with cytostatic and radiation therapy of tumors, psoriasis, solid therapy corticosteroids. While the application of the drug in the treatment of epilepsy in children (increased biosynthesis of serotonin). APPLICATION: inside after eating. Doses set depending on the concentration of uric acid in the blood. The minimum daily therapeutic dose for adults is 0.1 g, maximum - 0.8 g typically at a moderate hyperuricemia (70-100 mg / l) is prescribed by 0.2-0.4 g / day 1-2 times per day for 2-3 weeks, then move on to receive a maintenance dose - 0.2-0.3 g / day in 2-3 divided doses. In severe forms of gout, significant deposits of urate in the tissues and severe hyperuricemia (excess of 80-100 mg / l), the medication prescribed fractional (less than 0.2 g per dose) to 0.6-0.8 g / day for 2 - 4 weeks, and then move on to maintenance dose - 0.1-0.3 g / day, which take a long time, for several months. Using the drug for prevention of hyperuricemia during radiation therapy and chemotherapy of tumors average daily dose is 0.4, the drug is taken for 2-3 days prior to initiation of therapy (or both) and continue to the reception for a few more days after the end of a specific therapy. Children under the age of 6 years, the drug is administered in a daily dose of 5 mg / kg body weight, from 6 to 10 years - 10 mg / kg / day. The multiplicity of reception - 3-4 times a day. In the complex treatment of epilepsy in children the dose is 4-5 mg / kg 2 times a day for 10 days break between repeated courses - 1.5-2 months. If you omit the time of taking the drug, then take the next dose as soon as possible. If the next scheduled dose taken 12 hours or more, you need to take Allopurinol immediately, and the next dose - at the set time. If prior to the next dose has less than 12 hours, welcome to skip and then continue treatment as usual.